A Direct Synthesis of Oxazoles from Aldehydes

作者：Graham Thomas H^*

来源：Organic Letters, 2010, 12(16): 3614-3617.

DOI：10.1021/ol101346w

An expedient method for the direct conversion of aldehydes to 2,4-disubstituted oxazoles is presented. The method relies on the oxidation of an oxazolidine formed from the condensation of serine with an aldehyde and proceeds through a 2,5-dihydrooxazole intermediate. In contrast to standard methods that start from carboxylic acids, the use of aldehydes as starting materials does not require intermediate purification and affords the oxazoles under relatively mild conditions.

• 出版日期2010-8-20