Ultrafine Resveratrol Particles: Supercritical Antisolvent Preparation and Evaluation In Vitro and In Vivo

作者：Wang, Kunlun; Zhao, Xiuhua^*; Zu, Yuangang; Li, Jialei; Zhang, Xiaonan; Sun, Wei; Yu, Xinyang

来源：Advances in Materials Science and Engineering, 2015, 2015: 838513.

DOI：10.1155/2015/838513

• TRANS-RESVERATROL
• MICRONIZATION
• RECRYSTALLIZATION
• BIOAVAILABILITY
• MODEL
• WINE

Ultrafine resveratrol (u-Res) particles were prepared through the SAS process. The orthogonal method was used to optimize the factors of the SAS process. The size of u-Res reached 0.68 mu m under the optimum conditions. The characterization of the u-Res particles was tested by many analysis methods. The chemical structure of Res was unaffected by the SAS process. The degree of crystallinity of the u-Res particles greatly reduced. The purity of the u-Res particles increased from 98.5% to 99.2% during the SAS process. The u-Res particles had greater saturation solubility and dissolution rate than the raw-Res (r-Res) particles. The radical scavenging activity and bioavailability of the u-Res in vivo were 1.9 times of the r-Res.

• 出版日期2015
• 单位东北林业大学