Granular dynamics simulations of the effect of grain size dispersity on uniaxially compacted powder blends

作者：Dutt Meenakshi^*; Elliott James A

来源：Granular Matter, 2014, 16(2): 243-248.

DOI：10.1007/s10035-013-0463-3

• Discrete element modeling
• Size dispersity
• Particle packing

We investigate, via granular dynamics simulations, the influence of particle size dispersity on the packing characteristics of uniaxially compacted pharmaceutical blends. We employ reduced models of representative pharmaceutical excipient blends comprised of one, two, four and six components of different size, where the grain size in each component is distinct. We investigate the particle dynamics and reorganization during the compaction phase after the blend has been poured into a tablet die. For small strains, we demonstrate the packing fraction of the powder blends to scale linearly with the axial strain. We do not observe any significant variation in the stress response of the blend with particle size dispersity at small strains, but the mixtures with greater particle size dispersity remain compactible up to higher strains than the less polydisperse mixtures.

• 出版日期2014-4
• 单位rutgers