A clinicopathological, immunohistochemical and neuroradiological study of eight patients with central neurocytoma

作者：Jaiswal Sushila^*; Vij Mukul; Rajput Dinesh; Mehrotra Anant; Jaiswal Awadhesh Kumar; Srivastava Arun Kumar; Behari Sanjay; Krishnani Narendra

来源：Journal of Clinical Neuroscience, 2011, 18(3): 334-339.

DOI：10.1016/j.jocn.2010.05.031

• Brain tumor
• Central liponeurocytoma
• Central neurocytoma
• Immunohistochemistry

Central neurocytomas are low-grade tumors of neuronal origin located in the lateral ventricle that present predominantly with raised intracranial pressure. In this retrospective study, we investigated the clinical, radiological, histopathological and immunohistochemical features of eight patients (seven males and one female; age range 16-61 years; mean = 35.1 years) with neurocytoma. Raised intracranial pressure was the most common presenting feature. In addition, one patient presented with marked visual deterioration and one presented with a visual field defect. All lesions were located in the lateral ventricle (right lateral ventricle: four patients, left lateral ventricle: three patients, both ventricles: one patients). Radiology showed marked intratumoral calcification in two patients. Total microsurgical excision was achieved in seven patients. Histopathology showed sheets of monotonously small-to-medium-sized neoplastic cells with uniform round-to-oval nuclei and inconspicuous nucleoli. Immunohistochemistry was positive for synaptophysin and neuron-specific enolase (NSE) in all tumors, and glial fibrillary acidic protein was focally positive in two patients. One patient had lipomatous differentiation within the tumor. No recurrence was noted in any of our patients until the last follow-up; however, there were two deaths in our series.

• 出版日期2011-3
• 单位河北医科大学