MAPPING OF THE GENE FOR HORMONE-SENSITIVE LIPASE (LIPE) TO CHROMOSOME 19Q13.1-]Q13.2

作者：LEVITT RC; LIU Z; NOURI N; MEYERS DA; BRANDRIFF B; MOHRENWEISER HM

来源：Cytogenetics and Cell Genetics, 1995, 69(3-4): 211-214.

DOI：10.1159/000133966

Free fatty acids are the major source of fuel for mammals, and hormone sensitive lipase (LIFE) plays a critical role in lipid metabolism by mobilizing free fatty acids from stored triglycerides. We have identified and sequenced a partial cDNA for LIFE. Cosmids were identified by hybridization and mapped to 19q13.1-->q13.2 by FISH. Direct sequence analysis of a 1 kb segment of cosmid 26710 identifies a dinucleotide repeat in an intron upstream of exon 8 of human LIFE. This marker was heterozygous 82% of the time with 12 alleles (166-190 bp) detected in 122 chromosomes. The most likely order for this gene is: qter-[D19S178/LIPE]-(3 cM)-D19S47-(1 cM)-D19S190-RYR1-cen.

• 出版日期1995