Embolization therapy for benign prostatic hyperplasia: Influence of embolization particle size on gland perfusion

作者：Brook Olga Rachel^*; Faintuch Salomao; Brook Alexander; Goldberg S Nahum; Rofsky Neil M; Lenkinski Robert E

来源：Journal of Magnetic Resonance Imaging, 2013, 38(2): 380-387.

DOI：10.1002/jmri.23981

• dynamic contrast enhanced MRI
• prostatic artery embolization
• canine prostate
• benign prostatic hyperplasia

Purpose: To assess the influence of embolic size on the therapy response of prostatic arterial embolization (PAE) based on perfusional changes seen on dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI).
Materials and Methods: Twelve beagles underwent PAE, four dogs with each particle size: A: 100-300 m; B: 300-500 m; and C: 500-700 m. Prior to and 1 month after the embolization all dogs underwent prostate DCE MRI.
Results: After embolization, time to maximal perfusion intensity for prostate parenchyma increased in B (188 vs. 135 sec, P = 0.023) and C (200 vs. 120 sec, P = 0.001), while it did not change for A (139 vs. 124 sec, P = 0.39). The maximal relative intensity increased after embolization in C (3.84 vs. 2.38, P < 0.001), while it did not change for A (2.50 vs. 2.44, P = 0.36) and B (3.23 vs. 2.9, P = 0.21). The extent of visualized intraprostatic urethral wall increased after embolization in B compared with A and C, 239.5 +/- 138.1% vs. 56.1 +/- 34.3, P = 0.04. Enhancement changes correlated with prostate volume changes: prostate volumes in A decreased less as compared with B and C (77 +/- 34% vs. 56 +/- 14%), P = 0.02.
Conclusion: The enhancement and morphological data are useful to monitor response to therapy after embolization. Embolization with 300-500 and 500-700 m particle may provide better results than with 100-300 m particles in a canine model. J. Magn. Reson. Imaging 2013;38:380-387.

• 出版日期2013-8