Neural Circuit Assembly: Economically Wired by a Single Cadherin

作者:Kaschula Richard*; Salecker Iris
来源:Current Biology, 2014, 24(12): R555-R557.
DOI:10.1016/j.cub.2014.04.038

摘要

Neurons are thought to acquire shapes and configurations consistent with the wiring optimization principle. A new study sheds light on the underlying molecular mechanisms by demonstrating that N-cadherin-mediated differential adhesion determines relative neurite positioning in developing columnar synaptic modules.