The selectable antibiotic marker, tetA(C), increases Pseudomonas aeruginosa susceptibility to the herbicide/superoxide generator, paraquat

作者：Leesukon Panithi; Wirathorn Wilaiwan; Chuchue Tatsanee; Charoenlap Nisanart; Mongkolsuk Skorn^*

来源：Archives of Microbiology, 2013, 195(9): 671-674.

DOI：10.1007/s00203-013-0913-7

• Susceptibility
• TetA(C) protein
• Paraquat
• Pseudomonas aeruginosa
• Gram-negative bacteria

The presence of the widely used selectable antibiotic marker, tetA(C), unexpectedly increased the sensitivity of Pseudomonas aeruginosa PAO1 to the superoxide-generating herbicide, paraquat. A DNA fragment spanning the first 99 amino acids of TetA(C) was sufficient to confer paraquat sensitivity. The TetA(C)-induced paraquat sensitive phenotype was observed in other Gram-negative bacteria such as Agrobacterium tumefaciens, Salmonella enterica ser.

• 出版日期2013-9