An alignment-free method to find and visualise rearrangements between pairs of DNA sequences

作者:Pratas Diogo*; Silva Raquel M; Pinho Armando J; Ferreira Paulo J S G
来源:Scientific Reports, 2015, 5(1): 10203.
DOI:10.1038/srep10203

摘要

Species evolution is indirectly registered in their genomic structure. The emergence and advances in sequencing technology provided a way to access genome information, namely to identify and study evolutionary macro-events, as well as chromosome alterations for clinical purposes. This paper describes a completely alignment-free computational method, based on a blind unsupervised approach, to detect large-scale and small-scale genomic rearrangements between pairs of DNA sequences. To illustrate the power and usefulness of the method we give complete chromosomal information maps for the pairs human-chimpanzee and human-orangutan. The tool by means of which these results were obtained has been made publicly available and is described in detail.

  • 出版日期2015-5-18

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