Nobiletin, a Polymethoxy Flavonoid, Suppresses Bone Resorption by Inhibiting NF kappa B-Dependent Prostaglandin E Synthesis in Osteoblasts and Prevents Bone Loss Due to Estrogen Deficiency

作者：Harada Suguru; Tominari Tsukasa; Matsumoto Chiho; Hirata Michiko; Takita Morichika; Inada Masaki; Miyaura Chisato^*

来源：Journal of Pharmacological Sciences, 2011, 115(1): 89-93.

DOI：10.1254/jphs.10193SC

• polymethoxy flavonoid
• bone resorption
• osteoporosis

Nobiletin, a polymethoxy flavonoid, prevents cancer and inflammation, but the roles of nobiletin in bone are unclear. We examined the effects of nobiletin on bone resorption in vitro and on bone mass in ovariectomized (OVX) mice in vivo. In vitro, nobiletin suppressed osteoclast formation and bone resorption induced by interleukin (IL)-1. Nobiletin suppressed the expression of cyclooxygenase-2, NF kappa B-dependent transcription, and prostaglandin E (PGE) production induced by IL-1 in osteoblasts. OVX mice showed severe bone loss in the femur by increased bone resorption due to estrogen deficiency, and nobiletin significantly restored the bone mass. Nobiletin could be beneficial to bone health in postmenopausal women.

• 出版日期2011-1