Association of monocyte to high-density lipoprotein cholesterol ratio with carotid artery intima-media thickness in patients with systemic lupus erythematosus

作者：Wang, Qian; Meng, Yan; Cao, Wenyan; Du, Wenjing; Liu, Yumei; Yan, Yi; Luo, Li; Ma, Xiumin^*

来源：Biomarkers in Medicine, 2018, 12(4): 359-364.

DOI：10.2217/bmm-2016-0362

• carotid artery intima-media thickness
• hypertension
• inflammation
• monocyte to high-density lipoprotein cholesterol ratio
• oxidative stress
• systemic lupus erythematosus

Aim: The purpose of this study was to evaluate the relationship between monocyte to high-density lipoprotein cholesterol ratio (MHR) and carotid atherosclerostic plaque in patients with systemic lupus erythematosus (SLE). Methods: A total of 214 SLE patients were divided into two groups according to the results of ultrasonic examination: carotid arterial atherosclerotic plaque groups and noncarotid arterial atherosclerosis groups. Results: The values of monocyte to high-density lipoprotein-cholesterol ratio (MHR) increase in carotid arterial atherosclerotic plaque groups compared with noncarotid arterial atherosclerosis groups (0.32 +/- 0.18 vs 0.26 +/- 0.15; p = 0.015). There was a significant correlation between MHR and carotid artery intima-media thickness (r = 0.228; p = 0.001) in patients with SLE. Conclusion: Our study suggests that the values of MHR could be a marker to assess carotid artery intima-media thickness in patients with SLE.

• 出版日期2018-4
• 单位新疆医科大学; 新疆维吾尔自治区人民医院