Asymmetric Diastereoselective Synthesis of Spirocyclopropane Derivatives of Oxindole

作者：Oseka Maksim; Noole Artur; Zari Sergei; Oeeren Mario; Jaerving Ivar; Lopp Margus; Kanger Tonis^*

来源：European Journal of Organic Chemistry, 2014, 2014(17): 3599-3606.

DOI：10.1002/ejoc.201402061

• Organocatalysis
• Asymmetric synthesis
• Cyclization
• Michael addition
• Small ring systems

A new asymmetric organocatalytic synthesis of spirocyclopropane oxindoles has been developed. The method is based on the Michael addition of N-Boc-protected 3-chlorooxindole to unsaturated 1,4-dicarbonyl compounds, affording trans-substituted spirocyclopropane oxindole derivatives in high diastereo- and enantioselectivity.

• 出版日期2014-6