Microwave-assisted synthesis of symmetrical and unsymmetrical N,N '-disubstituted thioureas and ureas over MgO in dry media

作者：Valizadeh Hassan^*; Dinparast Leila

来源：Monatshefte fur Chemie, 2012, 143(2): 251-254.

DOI：10.1007/s00706-011-0583-6

• N-Monosubstituted hydroxylamines
• Isocyanate
• Isothiocyanate
• Microwave irradiation
• Solvent-free

Under mild microwave irradiation conditions a variety of symmetrical and unsymmetrical N,N'-disubstituted thioureas and ureas were prepared via the reaction of N-monosubstituted hydroxylamines with isocyanate and isothiocyanate derivatives over MgO under solvent-free conditions. This new method afforded satisfactory results with good yields, short reaction time, and simplicity in the experimental procedure.

• 出版日期2012-2