Association of HLA DRB1 alleles with juvenile idiopathic arthritis in Mexicans

作者：Silva Ramirez B; Cerda Flores R M; Rubio Perez N; Vargas Alarcon G; Perez Hernandez N; Granados Arriola J; Burgos Vargas R^*

来源：Clinical and Experimental Rheumatology, 2010, 28(1): 124-127.

• Juvenile idiopathic arthritis
• HLA-DRB1
• molecular class II analysis

Objective
The aim of the study was to investigate association between HLA class II alleles and juvenile idiopathic arthritis (JIA) in Mexican patients.
Patients and methods
We typed 120 patients with JIA and 99 healthy controls for HLA class II alleles were performed by PCR-SSO. Differences between the whole group JIA and its subtypes and controls were calculated by using the chi(2); p-values were corrected (pc) with Bonferroni's test.
Results
The alleles HLA-DRB1*01 (pc=0.00083) and HLA-DRB1*04 (pc=0.0049) were strongly associated with systemic JIA, while HLA-DRB1*11 and HLA-DRB1*14 were found to have decreased frequencies in the patients with systemic JIA compared to the controls. Two alleles were found to have increased frequencies with JIA oligoarthritis subgroup, HLA-DRB1*11 (p=0.01, pc=NS) and HLA-DRB1*13 (p=0.01, pc=NS). The HLA-DRB1*04 was fund increased frequencies with susceptibility for RE negative and RF positive polyarthritis. A subgroups (p correction resulted in loss of significance). In contrast two alleles HLA-DRB1*07 and HLA-DRB1*14 were fund decreased frequencies only patients RE positive polyarthritis JIA subgroup compared to the controls (pc=NS).
Conclusion
The profile of HLA-DRB1 alleles associations in Mexican with JIA were somewhat distinct from association typically found in Caucasians.

• 出版日期2010-2