A new hydroxydiphosphine as a ligand for Rh(I)-catalyzed enantioselective hydrogenation

作者：Komarov IV^*; Monsees A; Kadyrov R; Fischer C; Schmidt U; Borner A

来源：Tetrahedron: Asymmetry , 2002, 13(15): 1615-1620.

DOI：10.1016/S0957-4166(02)00372-5

A new diphosphine ligand bearing a hydroxy group in the backbone was synthesized starting from 9-bromocamphor. The rhodium(I) complex based on this ligand was tested in the hydrogenation of alpha- and beta-amino acid precursors. The activity and selectivity of the catalyst were found to be strongly dependent upon the nature of the substrate. Thus. beta-acetylamino carboxylates were obtained with up to 97% ee.

• 出版日期2002-8-14