A comparative evaluation of biological activities and bioactive compounds of the seagrasses Zostera marina and Zostera noltei from southern Portugal

作者：Custodio Luisa^*; Laukaityte Simona; Engelen Aschwin H; Rodrigues Maria Joao; Pereira Hugo; Vizetto Duarte Catarina; Barreira Luisa; Rodriguez Hortensia; Albericio Fernando; Varela Joao

来源：Natural Product Research, 2016, 30(6): 724-728.

DOI：10.1080/14786419.2015.1040791

• cytotoxicity
• oxidative stress
• PUFA
• rosmarinic acid
• seagrasses

This work assessed the antioxidant potential, acetylcholinesterase (AChE) inhibition and the in vitro cytotoxic activity of extracts of the seagrasses Zostera marina and Zostera noltei collected from southern Portugal. The total phenolic contents (TPCs), the rosmarinic acid (RA) concentration (HPLC/DAD) and the fatty acid (FA) profile (GC/MS) are also described. Z. marina had the highest TPC, radical scavenging activity against DPPH radicals and copper chelating activity. Z. noltei had metal chelation capacity to copper and iron ions. None of the species was able to inhibit AChE. Both seagrasses had high levels of polyunsaturated FAs. Z. marina significantly and selectively reduced the viability of tumorous neuronal cells. Z. noltei was highly toxic for the three cell lines tested and was selective against hepatocarcinoma cells at the concentration of 100g/mL. RA was the main compound identified in Z. marina, but not in Z. noltei.

• 出版日期2016-3-18