A diplotype in the lymphotoxin alpha gene is associated with differential expression of LTA mRNA induced by Gram-positive and Gram-negative bacteria

作者：Temple S E L^*; Almeida C M; Cheong K Y; Wunderink R G; Waterer G W

来源：International Journal of Immunogenetics, 2007, 34(3): 157-160.

DOI：10.1111/j.1744-313X.2007.00674.x

We sequenced the lymphotoxin alpha (LTA) promoter and identified LTA10G>A in strong linkage with LTA252G>A and LTA723C>A. Stimulated cells from LTA723AA: LTA252GG:LTA10AA individuals had significantly higher LTA mRNA levels than LTA723CC:LTA252AA:LTA10GG and LTA723AA:LTA252AG:LTA10GA individuals, suggesting that this diplotype may contain a functional polymorphism explaining the observed disease associations with LTA252G>A.

• 出版日期2007-6
• 单位西北大学