Avidity of Antibodies against Infecting Pneumococcal Serotypes Increases with Age and Severity of Disease

作者：Cremers Amelieke J H^*; Lut Jonneke; Hermans Peter W M; Meis Jacques F; de Jonge Marien I; Ferwerda Gerben

来源：Clinical and Vaccine Immunology, 2014, 21(6): 904-907.

DOI：10.1128/CVI.00147-14

The incidence of invasive pneumococcal disease (IPD) rises with age. Among adult IPD patients, the avidity of antipneumococcal polysaccharide antibodies against the infecting serotype increased with age and severity of disease, indicating that susceptibility to IPD in the elderly may rather be due to flaws in other aspects of opsonophagocytosis.

• 出版日期2014-6