A Facile Synthesis of Enantiomerically Pure (R)-6-Arylbinols

作者：Wang Wenling; Long Yuhua; Zou Zhifu; Yang Dingqiqo^*

来源：Chinese Journal of Chemistry, 2012, 30(5): 1092-1096.

DOI：10.1002/cjoc.201100679

• (R)-1
• 1'-bi-2-naphthols derivatives
• Suzuki cross coupling reaction
• chiral auxiliary
• synthesis

This work reported a convenient method for the preparation of enantiomerically pure 6-aryl-2,2'-dihydroxy-1,1'-binaphthyl derivatives starting from the commercially available (R)-2,2'-hydroxy-1,1'-binaphthyl [(R)-1] via bromination, hydrolysis and Suzuki cross coupling reaction. This novel synthetic method was characterized with high regioselectivity, simple operation, mild reaction conditions, and excellent yield (up to 73%). On the other hand, we synthesized the target unknown compounds, which were confirmed by IR, 1H NMR, 13C NMR, MS and elementary analysis.

• 出版日期2012-5
• 单位华南师范大学