Acute effects of steroid hormones and neuropeptides on human social-emotional behavior: A review of single administration studies

作者：Bos Peter A^*; Panksepp Jaak; Bluthe Rose Marie; van Honk Jack

来源：Frontiers in Neuroendocrinology, 2012, 33(1): 17-35.

DOI：10.1016/j.yfrne.2011.01.002

• Social behavior
• Testosterone
• Estradiol
• Vasopressin
• Oxytocin
• Hormone administration
• Humans

Steroids and peptides mediate a diverse array of animal social behaviors. Human research is restricted by technical-ethical limitations, and models of the neuroendocrine regulation of social-emotional behavior are therefore mainly limited to non-human species, often under the assumption that human social-emotional behavior is emancipated from hormonal control. Development of acute hormone administration procedures ill human research, together with the advent of novel non-invasive neuroimaging techniques, have opened up opportunities to systematically study the neuroendocrinology of human social-emotional behavior. Here, we review all placebo-controlled single hormone administration studies addressing human social-emotional behavior, involving the steroids testosterone and estradiol, and the peptides oxytocin and vasopressin. These studies demonstrate substantial hormonal control over human social-emotional behavior and give insights into the underlying neural mechanisms. Finally, we propose a theoretical model that synthesizes detailed knowledge of the neuroendocrinology of social-emotional behavior in animals with the recently gained data from humans described in our review.

• 出版日期2012-1