Analysis of Levodopa in the Presence of Vitamin B-6 Using Carbon Paste Electrode Modified with 1-Butyl-3 methylimidazolium Hexafluorophosphate and CuO Nanoparticles

作者：Karimi Maleh Hassan; Shojaei Moein; Amini Fatemeh; Akbari Ahmad

来源：Electroanalysis, 2017, 29(8): 1854-1859.

DOI：10.1002/elan.201600785

<jats:title>Abstract</jats:title><jats:p>A carbon paste electrode modified with 1‐butyl‐3‐methylimidazolium hexafluorophosphate ionic liquid (BMIPF6) and CuO nanoparticles (CuO/NPs) (CPE/BMIPF<jats:sub>6</jats:sub>/CuO/NPs) was fabricated and used for square wave voltammetric analysis of levodopa in the presence of vitamin B<jats:sub>6</jats:sub>. The elemental analysis, SEM and XRD methods were used for characterization of synthesized CuO nanoparticle. CPE/BMIPF<jats:sub>6</jats:sub>/CuO/NPs exhibited high electrical conductivity toward the electro‐oxidation of levodopa at a pH=7.0 as best experimental condition. Using CPE/BMIPF<jats:sub>6</jats:sub>/CuO/NPs the levodopa and vitamin B<jats:sub>6</jats:sub> peaks are separated and oxidized at potentials of 0.565 V and 0.835 V, respectively; hence levodopa can be detected in the presence of vitamin B<jats:sub>6</jats:sub>. The electrochemical response shows a linear relationship from concentration of levodopa and vitamin B<jats:sub>6</jats:sub> in the ranges of 0.06‐1000 μM and 0.1‐700.0 μM, respectively. Finally, CPE/BMIPF<jats:sub>6</jats:sub>/CuO/NPs were applied as high performance tool for determination of levodopa and vitamin B<jats:sub>6</jats:sub> in real samples.</jats:p>

• 出版日期2017-8