Norovirus genetic diversity and evolution: implications for antiviral therapy

作者:Rocha Pereira Joana; Van Dycke Jana; Neyts Johan
来源:Current Opinion in Virology, 2016, 20: 92-98.
DOI:10.1016/j.coviro.2016.09.009

摘要

Human noroviruses are the leading cause of foodborne illness causing both acute and chronic gastroenteritis. In recent years, a number of vaccine candidates entered (pre-) clinical development and the first efforts to develop antiviral therapy have been made. We here discuss aspects of norovirus genetic evolution, persistence in immunocompromised patients as well as the risk and potential consequences of resistance development toward future antiviral drugs.