Acetic anhydride-promoted one-pot condensation of 2,4-thiazolidinedione with bisulfite adducts of aldehydes

作者：Mohanty Sandeep^*; Roy Amrendra Kumar; Kumar Vinay K P; Reddy Sandeep G; Karmakar Arun Chandra

来源：Tetrahedron Letters, 2014, 55(33): 4585-4589.

DOI：10.1016/j.tetlet.2014.06.082

• Acetic anhydride
• Aromatic bisulfite adducts
• Analysis of variance (ANOVA)
• Regression analysis

We describe a simple and efficient one-pot method for condensing bisulfite adducts of aromatic aldehydes directly with 2,4-thiazolidinedione catalyzed by acetic anhydride. The two main highlights of this study are the one-pot condensation of bisulfite adducts with 2,4-thiazolidinedione in non-aqueous media and the use of Design of Experiment to understand and optimize the reaction conditions. This methodology was then generalized using other active methylene compounds, such as malononitrile.

• 出版日期2014-8-13