Design and In Vitro Assessment of an Improved, Low-Resistance Compliant Thoracic Artificial Lung

作者：Schewe Rebecca E; Khanafer Khalil M; Arab Aarthi; Mitchell Jeffrey A; Skoog David J; Cook Keith E^*

来源：ASAIO Journal, 2012, 58(6): 583-589.

DOI：10.1097/MAT.0b013e31826dcd23

• compliant thoracic artificial lung
• fluid-structure interaction modeling
• impedance

Current thoracic artificial lungs (TALs) have blood flow impedances greater than the natural lungs, which can result in abnormal pulmonary hemodynamics. This study investigated the impedance and gas transfer performance of a compliant TAL (cTAL). Fluid-structure interaction analysis was performed using ADINA (ADINA R&D Inc., Watertown, MA) to examine the effect of the inlet and outlet expansion angle,., on device impedance and blood flow patterns. Based on the results, the theta = 45 degrees model was chosen for prototyping and in vitro testing. Glycerol was pumped through this cTAL at 2, 4, and 6 L/min at 80 and 100 beats/min, and the zeroth and first harmonic impedance moduli, Z(0) and Z(1), were calculated. Gas transfer testing was conducted at blood flow rates of 3, 5, and 7 L/min. Fluid-structure interaction results indicated that the 45 model had an ideal combination of low impedance and even blood flow patterns and was thus chosen for prototyping. In vitro, Z(0) = 0.53 +/- 0.06 mm Hg/(L/min) and Z(1) = 0.86 +/- 0.08 mm Hg/(L/min) at 4 L/min and 100 beats/min. Outlet PO2 and SO2 values were above 200 mm Hg and 99.5%, respectively, at each flow rate. Thus, the cTAL had lower impedance than hard shell TALs and excellent gas transfer. ASAIO Journal 2012;58:583-589.

• 出版日期2012-12