An efficient synthesis of (Z)-alpha-fluorochalcones via the palladium-catalyzed cross-coupling reaction of (Z)-alpha-fluorocinnamoyl chloride with boronic acids

作者：Eddarir Said; Kajjout Mohammed; Rolando Christian^*

来源：Tetrahedron, 2013, 69(6): 1735-1738.

DOI：10.1016/j.tet.2012.12.025

• alpha-Fluorochalcones
• Palladium
• Cross-coupling
• Catalysis

An efficient synthesis of alpha-fluorochalcones (1,3-diphenyl-2-fluoroprop-2-en-1-one) based on the Suzuki-Miyaura palladium-catalyzed cross-coupling reaction of arylboronic acids with alpha-fluorocinnamoyl chlorides in the presence of Cs2CO3 in toluene is described. This approach allows the synthesis of fluorinated analogues of functionalized natural chalcones.

• 出版日期2013-2-11