Age-related changes in rat prostate tissue; perspective of protein oxidation

作者：Uzun Duygu; Yanar Karolin; Atukeren Pinar; Cebe Tamer; Mengi Murat; Ozan Tuna; Kunbaz Ahmad; Kuruc Aylin Irmak; Cakatay Ufuk^*; Aydin Seval

来源：Aging Male, 2015, 18(1): 54-59.

DOI：10.3109/13685538.2014.951921

• Aging
• antioxidant capacity
• lipid peroxidation
• prostate
• protein oxidation

Background: Increased systemic oxidative stress is considered as an important risk factor for prostate cancer occurrence; however, the relationship between impaired redox homeostasis of prostate tissue and aging remains unclear. Objective: In our study, we hypothesized that age-related deterioration of redox homeostasis in prostate tissue may be considered as a predisposing factor for prostate cancer occurrence.
Methods: Sprague-Dawley rats were divided into two groups as young control (5 months) and naturally aged (24 months). We investigated the levels of oxidant and antioxidant parameters in prostate tissue.
Results: Advanced oxidation protein products, protein carbonyl, non-protein thiol and lipid hydroperoxides levels of aged rats were significantly higher than in the young control rats (p<0.01, p<0.05, p<0.001, p<0.05, respectively). Additionally, antioxidant activity of Cu-Zn-superoxide dismutase in elderly group was significantly lower than young controls (p<0.05).
Conclusions: We suggest that increased non-protein thiol levels found in aged rats may prevent further dissemination of oxidative protein damage. We also propose that the increased levels of oxidative protein damage markers and decreased Cu-Zn superoxide dismutase activity in aged prostate may be considered as a predisposing factor for prostate cancer. Further studies are warranted to clarify all these oxidative changes as initiation factors for prostate cancer in the association of aging with prostate cancer.

• 出版日期2015-3