A turn-on coordination nanoparticle-based fluorescent probe for phosphate in human serum

作者：Lin Na; Li Jian; Lu Zhixiang; Bian Longchun; Zheng Liyan^*; Cao Qiue; Ding Zhongtao

来源：Nanoscale, 2015, 7(11): 4971-4977.

DOI：10.1039/c5nr00515a

Coordination nanoparticles (CNPs) are becoming attractive platforms for chemical sensing applications because their unique adjustable properties offer the opportunity to design various luminescent nanoprobes. Here, we present a CNP-based fluorescent nanoprobe, in which fluorophores (rhodamine B, RB) and quenchers (methylene blue, MB) were spontaneously enfolded by coordination networks self-assembled of adenine, biphenyl-4,4'-dicarboxylic acid (BDA) and zinc ions. The aggregation of fluorophores and quenchers in CNPs resulted in a quenched state fluorescence of RB. RB and MB could be released from CNPs in the presence of phosphate, which triggered the fluorescence of RB. On the basis of recognition-driven disassembly principle, a novel turn-on fluorescent probe for the determination of PO43- with a wide response range (0.5-50 mu M) has been successfully applied in the detection of phosphate in human serum samples. This work not only develops a probe for phosphate but also provides a general strategy for designing nanoprobes or nanocarriers towards various targets by altering organic linkers or metal ions.

• 出版日期2015
• 单位云南大学