BODIPY: A Highly Versatile Platform for the Design of Bimodal Imaging Probes

作者：Lhenry Damien; Larrouy Manuel; Bernhard Claire; Goncalves Victor; Raguin Olivier; Provent Peggy; Moreau Mathieu; Collin Bertrand; Oudot Alexandra; Vrigneaud Jean Marc; Brunotte Francois; Goze Christine^*; Denat Franck

来源：Chemistry - A European Journal, 2015, 21(37): 13091-13099.

DOI：10.1002/chem.201501676

• BODIPY
• imaging agents
• macrocycles
• molecular imaging
• optical imaging
• positron emission tomography

In molecular imaging, multimodal imaging agents can provide complementary information, for improving the accuracy of disease diagnosis or enhancing patient management. In particular, optical/nuclear imaging may find important preclinical and clinical applications. To simplify the preparation of dual-labeled imaging agents, we prepared versatile monomolecular multimodal imaging probe (MOMIP) platforms containing both a fluorescent dye (BODIPY) and a metal chelator (polyazamacrocycle). One of the MOMIP was conjugated to a cyclopeptide (i.e., octreotide) and radiolabeled with In-111. In vitro and in vivo studies of the resulting bioconjugate were conducted, highlighting the potential of these BODIPY-based bimodal probes. This work also confirmed that the biovector and/or the bimodal probes must be chosen carefully, due to the impact of the MOMIP on the overall properties of the resulting imaging agent.

• 出版日期2015-9-7