A cancer-targetable copolymer containing tyrosine segments for labeling radioactive halogens

作者：Qi, Yu; Li, Najun^*; Xu, Qingfeng; Xia, Xuewei; Ge, Jianfeng; Lu, Jianmei

来源：Reactive and Functional Polymers, 2011, 71(4): 390-394.

DOI：10.1016/j.reactfunctpolym.2010.12.009

• Copolymer
• Synthesis
• Tyrosine
• Isotope
• Targeting

A series of cancer-targetable copolymers containing rhodamine and tyrosine segments were synthesized and further labeled with isotope I-125. Copolymers with different molecular weights (PRTH-1, PRTH-2 and PRTH-3) formed aggregates in water with average diameters of 66 nm, 191 nm and 137 nm, respectively. The cancer cell targeting properties of the copolymers were investigated by comparing BEL-7402 liver cancer cells and L-02 human normal liver cells. The results indicate that their targeting properties are related to the average diameters of the PRTH copolymers that self-assembled in water. PRTH-2 copolymers were selected as having the best targeting properties for cancer cells. The in vivo study of HepA mouse models based on single-photon emission computed tomography (SPECT) also showed good tumor-targeting properties of PRTH-2 labeled with I-125.

• 出版日期2011-4
• 单位宿州学院; 苏州大学