Nobiletin Protects Dopaminergic Neurons in the 1-Methyl-4-Phenylpyridinium-Treated Rat Model of Parkinson's Disease

作者：Jeong Kyoung Hoon; Jeon Min Tae; Kim Heung Deok; Jung Un Ju; Jang Min Cheol; Chu Jin Woo; Yang Seung Jun; Choi Il Yoon; Choi Myung Sook; Kim Sang Ryong^*

来源：Journal of Medicinal Food, 2015, 18(4): 409-414.

DOI：10.1089/jmf.2014.3241

• neuroprotection
• dopaminergic neuron
• MPP+
• nobiletin
• microglia
• GDNF

This study investigated the effect of nobiletin, a flavonoid found in citrus fruits, on the degeneration of dopaminergic (DA) neurons in a neurotoxin model of Parkinson's disease (PD). 1-Methyl-4-phenylpyridinium (MPP+) was unilaterally injected into the median forebrain bundle of rat brains (to generate a neurotoxin model of PD) with or without daily intraperitoneal injection of nobiletin. Our results showed that nobiletin treatment at 10 mg/kg bw, but not at 1 or 20 mg/kg bw, significantly protected DA neurons in the substantia nigra (SN) of MPP+-treated rats. In parallel to the neuroprotection, nobiletin treatment at 10 mg/kg inhibited microglial activation and preserved the expression of the glial cell line-derived neurotrophic factor, which is a therapeutic agent against PD, in the SN. These results suggest that the proper supplementation with nobiletin may protect against the neurodegeneration involved in PD.

• 出版日期2015-4-1