Scarless Wound Healing: Chasing the Holy Grail

作者：Walmsley Graham G; Maan Zeshaan N; Wong Victor W; Duscher Dominik; Hu Michael S; Zielins Elizabeth R; Wearda Taylor; Muhonen Ethan; McArdle Adrian; Tevlin Ruth; Atashroo David A; Senarath Yapa Kshemendra; Lorenz H Peter; Gurtner Geoffrey C; Longaker Michael T^*

来源：Plastic and Reconstructive Surgery, 2015, 135(3): 907-917.

DOI：10.1097/PRS.0000000000000972

Over 100 million patients acquire scars in the industrialized world each year, primarily as a result of elective operations. Although undefined, the global incidence of scarring is even larger, extending to significant numbers of burn and other trauma-related wounds. Scars have the potential to exert a profound psychological and physical impact on the individual. Beyond aesthetic considerations and potential disfigurement, scarring can result in restriction of movement and reduced quality of life. The formation of a scar following skin injury is a consequence of wound healing occurring through reparative rather than regenerative mechanisms. In this article, the authors review the basic stages of wound healing; differences between adult and fetal wound healing; various mechanical, genetic, and pharmacologic strategies to reduce scarring; and the biology of skin stem/progenitor cells that may hold the key to scarless regeneration.

• 出版日期2015-3