ARID1A Mutations in Cancer: Another Epigenetic Tumor Suppressor?

作者：Wu Jennifer N; Roberts Charles W M^*

来源：Cancer Discovery, 2013, 3(1): 35-43.

DOI：10.1158/2159-8290.CD-12-0361

Although disordered chromatin organization has long been recognized as a feature of cancer, the molecular underpinnings of chromatin structure, epigenetic regulation, and their relationships to transcription are only beginning to be understood. Cancer genome sequencing studies have revealed a novel theme: frequent mutation of epigenetic regulators. Among these, the ARID1A/BAF250A subunit of the SWI/SNF (BRG1-associated factors) chromatin remodeling complex has emerged as recurrently mutated in a broad array of tumor types. We review the genomic and functional data supporting classification of ARID1A as a tumor suppressor.

• 出版日期2013-1