Toll-like receptors as therapeutic targets in cystic fibrosis

作者：Greene Catherine M^*; Branagan Peter; McElvaney Noel G

来源：Expert Opinion on Therapeutic Targets, 2008, 12(12): 1481-1495.

DOI：10.1517/14728220802515293

• cystic fibrosis
• inflammation
• innate immunity
• therapeutics
• toll-like receptors

Background: Toll-like receptors (TLRs) are pattern recognition receptors that act as a first-line of defence in the innate immune response by recognising and responding to conserved molecular patterns in microbial factors and endogenous danger signals. Cystic fibrosis (CF)-affected airways represent a milieu potentially rich in TLR agonists and the chronic inflammatory phenotype evident in CIF airway epithelial cells is probably due in large part to activation of TLRs. Objective/methods: To examine the prospects of developing novel therapies for CF by targeting TLRs. We outline the expression and function of TLRs and explore the therapeutic potential of naturally-occurring and synthetic TLR inhibitors for CF. Results/conclusion: Modulation of TLRs has therapeutic potential for the inflammatory lung manifestations of CF.

• 出版日期2008-12