Antibacterial compound from the endophytic fungus Phomopsis longicolla isolated from the tropical red seaweed Bostrychia radicans

作者：Erbert Cintia^*; Lopes Adriana A; Yokoya Nair S; Furtado Niege A J C; Conti Raphael; Pupo Monica T; Lopes Joao Luis C; Debonsi Hosana M

来源：Botanica Marina, 2012, 55(4): 435-440.

DOI：10.1515/bot-2011-0023

• antibacterial activity
• Bostrychia radicans
• endophytic fungi
• marine algae
• Phomopsis longicolla

Endophytic fungi isolated from the red seaweed Bostrychia radicans were studied to identify their molecularly diverse and biologically active natural chemical products. According to 28S ribosomal DNA-based identification, the strain named C81 was 98% identical to Phomopsis longicolla. This strain was cultivated in solid rice medium and produced three major metabolites identified as 18-deoxycytochalasin H (1), mycophenolic acid (2), and dicerandrol C (3). The chemical structures of these compounds were elucidated by 1D and 2D nuclear magnetic resonance as well as by mass spectrometry. Dicerandrol C had significant antimicrobial activity against Staphylococcus aureus (ATCC 6538) and Staphylococcus saprophyticus (ATCC 15305), with minimum inhibitory concentrations of 1 and 2 mu g ml(-1) (1.33 and 2.66 mu M), respectively. These results show the presence of promising metabolites and indicate that these natural products should be considered in the development of new antibiotics.

• 出版日期2012-8