Alcohol and other substance use after bariatric surgery: prospective evidence from a US multicenter cohort study

作者：King Wendy C^*; Chen Jia Yuh; Courcoulas Anita P; Dakin Gregory F; Engel Scott G; Flum David R; Hinojosa Marcelo W; Kalarchian Melissa A; Mattar Samer G; Mitchell James E; Pomp Alfons; Pories Walter J; Steffen Kristine J; White Gretchen E; Wolfe Bruce M; Yanovski Susan Z

来源：Surgery for Obesity and Related Diseases, 2017, 13(8): 1392-1404.

DOI：10.1016/j.soard.2017.03.021

• Roux-en-Y gastric bypass
• Gastric band
• Obese
• Substance use
• Disorder
• Addiction
• Abuse
• Treatment

Background: Empirical evidence suggests Roux-en-Y gastric bypass (RYGB) increases risk of developing alcohol use disorder (AUD). However, prospective assessment of substance use disorders (SUD) after bariatric surgery is limited.
Objective: To report SUD-related outcomes after RYGB and laparoscopic adjustable gastric banding (LAGB). To identify factors associated with incident SUD-related outcomes.
Setting: 10 U.S. hospitals
Methods: The Longitudinal Assessment of Bariatric Surgery-2 is a prospective cohort study. Participants self-reported past-year AUD symptoms (determined by the Alcohol Use Disorders Identification Test), illicit drug use (cocaine, hallucinogens, inhalants, phencyclidine, amphetamines, or marijuana), and SUD treatment (counseling or hospitalization for alcohol or drugs) presurgery and annually postsurgery for up to 7 years through January 2015.
Results: Of 2348 participants who underwent RYGB or LAGB, 2003 completed baseline and followup assessments (79.2% women, baseline median age: 47 years, median body mass index 45.6). The year-5 cumulative incidence of postsurgery onset AUD symptoms, illicit drug use, and SUD treatment were 20.8% (95% confidence interval (CI): 18.5-23.3), 7.5% (95% CI: 6.1-9.1), and 3.5% (95% CI: 2.6-4.8), respectively, post-RYGB, and 11.3% (95% CI: 8.5-14.9), 4.9% (95% CI: 3.1-7.6), and.9% (95% CI:.4-2.5) post-LAGB. Undergoing RYGB versus LAGB was associated with higher risk of incident AUD symptoms (adjusted hazard ratio or AHR = 2.08 [95% CI: 1.51-2.85]), illicit drug use (AHR = 1.76 [95% CI: 1.07-2.90]) and SUD treatment (AHR = 3.56 [95% CI: 1.26-10.07]).
Conclusions: Undergoing RYGB versus LAGB was associated with twice the risk of incident AUD symptoms. One-fifth of participants reported incident AUD symptoms within 5 years post-RYGB. AUD education, screening, evaluation, and treatment referral should be incorporated in pre- and postoperative care. (Surg Obes Relat Dis 2017;13:1392-1404.

• 出版日期2017-8