Alkyldisulfanium Salts: Isolable, Electrophilic Sulfur Reagents Competent for Polyene Cyclizations

作者：Schevenels Florian T; Shen Minxing; Snyder Scott A^*

来源：Organic Letters, 2017, 19(1): 2-5.

DOI：10.1021/acs.orglett.6b02059

Tools that can effect electrophilic sulfur-promoted cation-pi cyclizations are generally lacking, especially using alkylsulfide-based reagents. Herein we report that combining three different 1,2-dithioethers with Cl-2 and SbCl5 generates isolable alkyldisulfanium salts that can effect such reactions. These new reagents can install -SMe, -SEt, and -SCH2CH2CF3 in modest, moderate, or good yield on diverse frameworks, including polyenes that terminate with electron-deficient groups. We also show that reagents such as dimethyl(methylthio)sulfonium tetrafluoroborate (DMTSF) can accomplish similar chemistry

• 出版日期2017-1-6