New Metabolites from Endophytic Fungus Chaetomium globosum CDW7

作者：Yan, Wei; Cao, Ling-Ling; Zhang, Yang-Yang; Zhao, Ran; Zhao, Shuang-Shuang; Khan, Babar; Ye, Yong-Hao^*

来源：Molecules, 2018, 23(11): 2873.

DOI：10.3390/molecules23112873

• Chaetomium globosum
• isocoumarin derivatives
• indole alkaloid
• antifungal activity

Five metabolites including two new ones, prochaetoviridin A (1) and chaetoindolin A (2), were isolated from the endophytic fungus Chaetomium globosum CDW7. Compounds 1 and 2 were characterized as an isocoumarin and an indole alkaloid derivative, respectively, with their structures elucidated by comprehensive spectroscopic analyses including high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), NMR, and circular dichroism (CD) comparison. Compounds 3-5 were identified as chaetoviridin A, chaetoglobosin R, and chaetoglobosin T, respectively. Chaetoviridin A (3) exhibited antifungal activity against Sclerotinia sclerotiorum with an EC50 value of 1.97 mu g/mL. In vivo test showed that 3 displayed a protective efficacy of 64.3% against rape Sclerotinia rot at the dosage of 200 mu g/mL, comparable to that of carbendazim (69.2%).

• 出版日期2018-11
• 单位南京农业大学