A genome-wide association study of direct gestation length in US Holstein and Italian Brown populations

作者：Maltecca C^*; Gray K A; Weigel K A; Cassady J P; Ashwell M

来源：Animal Genetics, 2011, 42(6): 585-591.

DOI：10.1111/j.1365-2052.2011.02188.x

• association study
• cattle
• direct gestation length

Direct gestation length influences economically important traits in dairy cattle that are related to birth and peri-natal survival of the calf. The objective of this study was to identify single nucleotide polymorphisms (SNPs) that are significantly associated with direct gestation length through a genome-wide association study. Data used in the analysis included 7 308 194 cow gestation lengths from daughters of 4743 United States Holstein sires in the Cooperative Dairy DNA Repository population and 580 157 gestation lengths from 749 sires in the Italian Brown population. Association analysis included 36 768 and 35 082 SNPs spanning all autosomes for Holstein and Brown Swiss, respectively. Multiple shrinkage Bayesian was employed. Estimates of heritability for both populations were moderate, with values of 0.32 (+/- 0.03) and 0.29 (+/- 0.02) for Holstein and Brown Swiss, respectively. A panel of SNPs was identified, which included SNPs that have significant effects on direct gestation length, of which the strongest candidate region is located on chromosome 18. Two regions not previously linked to direct calving ease and calf survival were identified on chromosome 7 and 28, corresponding to regions that contain genes related to embryonic development and foetal development. SNPs were also identified in regions that have been previously mapped for calving difficulty and longevity. This study identifies target regions for the investigation of direct foetal effects, which are a significant factor in determining the ease of calving.

• 出版日期2011-12