Assessment at 6 months may be warranted for patients with chronic myeloid leukemia with no major cytogenetic response at 3 months

作者：Nazha Aziz; Kantarjian Hagop; Jain Preetesh; Romo Carlos; Jabbour Elias; Quintas Cardama Alfonso; Luthra Raja; Abruzzo Lynne; Borthakur Gautam; Ravandi Farhad; Pierce Sherry; O' Brien Susan; Cortes Jorge^*

来源：Haematologica-The Hematology Journal, 2013, 98(11): 1686-1688.

DOI：10.3324/haematol.2013.090282

Response to tyrosine kinase inhibitors at three months is a predictor for long-term outcome in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors. We analyzed 456 newly diagnosed chronic myeloid leukemia patients treated with tyrosine kinase inhibitors to determine their outcome based on their response at six months. Forty-four (10%) patients did not achieve major cytogenetic response at three months: 18 of 67 (27%) patients treated with imatinib 400; 18 of 196 (9%) with imatinib 800; and 8 of 193 (4%) with 2nd generation tyrosine kinase inhibitors. Among them, 19 (43%) achieved major cytogenetic response at six months and subsequently had an overall outcome similar to the patients who achieved a major cytogenetic response at three months. In conclusion, the response to tyrosine kinase inhibitors at three months is a static, one-time measure. Assessing the response at six months of patients with poor response at three months may provide a better predictor for long-term outcome.

• 出版日期2013-11