A Novel Method for the Synthesis of (1,8-Dioxo-2,3,4,5,6,7,8,9-octahydro-1H-xanthen-9-yl)acetic Acids on Solid Phase

作者：Cravero Raquel M^*; Luna Liliana E; Barboza Andrea V

来源：Synthesis, 2011, (24): 4027-4032.

DOI：10.1055/s-0031-1289602

• polycycles
• tandem reactions
• cycloadditions
• Michael addition
• solid-phase synthesis

We report the first solid-phase synthesis of (1,8-dioxo-2,3,4,5,6,7,8,9-octahydro-1H-xanthen-9-yl)acetic acids via a tandem Michael-Michael cyclization with resin-bound propiolic acid as Michael acceptor and cyclohexanediones.

• 出版日期2011-12