Non-classical MHC Class I molecules regulating natural killer cell function

作者：Smyth Mark J^*; Sullivan Lucy C; Brooks Andrew G; Andrews Daniel M

来源：OncoImmunology, 2013, 2(3): e23336.

DOI：10.4161/onci.23336

• education
• inhibitory
• metastasis
• tumor immunosurveillance

Natural killer (NK) cells possess effector and immunoregulatory functions that are controlled by a myriad of receptor-ligand pairs, including human killer inhibitory receptor (KIR) and mouse Ly49-MHC class I interactions. We have recently shown that the NK cell inhibitory molecule Ly49A binds the non-classical MHC molecule H2-M3, thus regulating host innate immune responses to tumor initiation and metastasis.

• 出版日期2013-3-1