A convenient synthesis of chiral vinyl aziridines via aza-Barbier-Darzen type reaction

作者：Liu, Wen-Jie; Zhao, Yun-Hui; Sun, Xing-Wen^*

来源：Tetrahedron Letters, 2013, 54(28): 3586-3590.

DOI：10.1016/j.tetlet.2013.04.046

• Aza-Barbier-Darzen type reaction
• 1,3-Dibromoprop-1-ene
• (R)-N-tert-Butanesulfinyl imine
• Vinyl aziridine

A facile and efficient approach for the synthesis of chiral vinyl aziridines has been developed in moderate yields and high diastereoselectivities via Zn-promoted aza-Barbier-Darzen type reaction of (R)-N-tert-butanesulfinyl imines with 1,3-dibromoprop-1-ene.

• 出版日期2013-7-10
• 单位复旦大学