Atopic Diathesis in Hypohidrotic/Anhidrotic Ectodermal Dysplasia

作者：Koguchi Yoshioka Hanako^*; Wataya Kaneda Mari; Yutani Mizuki; Murota Hiroyuki; Nakano Hajime; Sawamura Daisuke; Katayama Ichiro

来源：Acta Dermato-Venereologica, 2015, 95(4): 476-479.

DOI：10.2340/00015555-1978

• hypohidrotic/anhidrotic ectodermal dysplasia
• hypohidrosis/anhidrosis
• atopic dermatitis
• periorbital eczema

Recently, patients with hypohidrotic/anhidrotic ectodermal dysplasia (H/AED) have been reported to have a higher prevalence of symptoms suggestive of atopic disorders than the general population. To better understand atopic diathesis in H/AED, 6 cases of clinically or genetically diagnosed H/AED were examined. The following criteria were evaluated with patient consent: sweating, blood test results, histopathology and filaggrin staining. Five of 6 H/AED cases displayed atopic dermatitis-like manifestations, and 3 of these 5 cases experienced periorbital lesions. Sweat ducts were not histopathologically observed, and filaggrin staining was similar to normal subjects. Serum IgE was elevated in 2 of the 3 patients. H/AED patients tended to present with atopic dermatitis-like eruptions with characteristics potentially indicative of periorbital lesions. Atopic diathesis in H/AED appeared not to be associated with filaggrin. We could speculate that hypohidrosis or anhidrosis itself might impair skin barrier function and contribute to atopic diathesis.

• 出版日期2015