Addition of carbamoylsilane to isatins: Highly efficient synthesis of 3-hydroxy-3-aminocarbonyl-2-oxindoles derivatives

作者：Liang, Jin-Yan; Wang, Hui; Yang, Yan-Li; Shen, Shou-Jie^*; Chen, Jian-Xin^*

来源：Tetrahedron Letters, 2017, 58(27): 2636-2639.

DOI：10.1016/j.tetlet.2017.05.051

• Carbamoylsilane
• Aminocarbonylation reaction
• Aminocarbonyl oxindole
• One-pot synthesis

The first addition reaction between isatins and carbamoysilane has been developed which provides 3hydroxy-3-aminocarbonyl-2-oxindoles core structures with excellent yields. Moreover, the reaction could undergo a one-pot synthesis process to furnish 3-hydroxy-3-aminocarbonyl-2-oxindole with gram-scale.

• 出版日期2017-7-5
• 单位山西师范大学