New indane and naphthalene derivatives from the rhizomes of Kniphofia reflexa Hutchinson ex Codd

作者：Sema Denis Kehdinga; Lannang Alain Meli^*; Tatsimo Simplice J N; Mujeeb ur Rehman; Yousuf Sammer; Zoufou Denis; Iqbal Urooj; Wansi Jean Duplex; Sewald Norbert; Choudhary M Iqbal

来源：Phytochemistry Letters, 2018, 26: 78-82.

DOI：10.1016/j.phytol.2018.05.025

• Kniphofia reflexa
• Indane
• Cytotoxicity
• LLC-MK2
• Naphthalene
• Anti-inflammatory

Two new (1-2) and eight known (3-10) secondary metabolites were isolated from the rhizomes of Kniphofia reflexa Hutchinson ex Codd. Among them, an indane derivative kniphofiarindane (1), and naphthalene derivative kniphofiarexine (2), were identified as new natural products. 1D- and 2D-NMR spectroscopic studies together with single-crystal X-ray diffraction techniques were employed in the structural elucidation of the new compounds, 1 and 2. These compounds were evaluated for their cytotoxic effect against kidney epithelial cell line (LLC-MK2). Compound 3 was found to be highly cytotoxic, while compounds 1, and 10 showed moderate cytotoxicity with CC50 values of 4.44 +/- 0.79, 16.35 +/- 1.54, and 11.24 +/- 1.22 mu g/mL, respectively against the tested standard Gleevec (Imatinib), (CC (50) = 18.50 +/- 1.21 mu g/mL). Compounds 8, and 9 also showed moderate anti-inflammatory activity (CC (50 )= 38.7 +/- 4.90, and 20.00 +/- 4.40 mu g/mL, respectively) against ROS production.

• 出版日期2018-8