Arylation of adamantanamines: VI. Palladium-catalyzed arylation of amines and diamines of the adamantane series with 3-bromopyridine

作者：Averin A D^*; Baranova T Yu; Abel A S; Kovalev V V; Buryak A K; Butov G M; Savelyev E N; Orlinson B S; Novakov I A; Beletskaya I P

来源：Russian Journal of Organic Chemistry, 2013, 49(1): 1-7.

DOI：10.1134/S1070428013010016

Palladium-catalyzed amination of 3-bromopyridine with amines of the adamantane series in the presence of Pd(dba)(2)/L [L = 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl or 2-dimethylamino-2'-dicyclohexylphosphinobiphenyl] gave the desired N-(pyridin-3-yl)-substituted amines in 74-97% yields. Diamines of the adamantane series reacted with 2 equiv of 3-bromopyridine in a complicated fashion to produce mono- and triaryl-substituted derivatives as by-products, while the yields of N,N'-diarylation products were 18-56%. DOI: 10.1134/S1070428013010016

• 出版日期2013-1