Maternal consumption of peanut during pregnancy is associated with peanut sensitization in atopic infants

作者：Sicherer Scott H^*; Wood Robert A; Stablein Donald; Lindblad Robert; Burks A Wesley; Liu Andrew H; Jones Stacie M; Fleischer David M; Leung Donald Y M; Sampson Hugh A

来源：Journal of Allergy and Clinical Immunology, 2010, 126(6): 1191-1197.

DOI：10.1016/j.jaci.2010.08.036

• Food allergy
• sensitization
• atopy
• peanut allergy

Background: Peanut allergy is typically severe, lifelong, and prevalent.
Objective: To identify factors associated with peanut sensitization.
Methods: We evaluated 503 infants 3 to 15 months of age (mean, 9.4 months) with likely milk or egg allergy but no previous diagnosis of peanut allergy. A total of 308 had experienced an immediate allergic reaction to cow's milk and/or egg, and 204 had moderate to severe atopic dermatitis and a positive allergy test to milk and/or egg. A peanut IgE level >= 5 kU(A)/L was considered likely indicative of peanut allergy.
Results: A total of 140 (27.8%) infants had peanut IgE levels >= 5 kU(A)/L. Multivariate analysis including clinical, laboratory, and demographic variables showed frequent peanut consumption during pregnancy (odds ratio, 2.9; 95% CI, 1.7-4.9; P < .001), IgE levels to milk (P = .001) and egg (P < .001), male sex (P = .02), and nonwhite race (P = .02) to be the primary factors associated with peanut IgE >= 5 kU(A)/L. Frequency of peanut consumption during pregnancy and breast-feeding showed a dose-response association with peanut IgE >= 5 kU(A)/L, but only consumption during pregnancy was a significant predictor. Among 71 infants never breast-fed, frequent consumption of peanut during pregnancy was strongly associated with peanut IgE >= 5 kU(A)/L (odds ratio, 4.99, 95% CI, 1.69-14.74; P < .004).
Conclusion: In this cohort of infants with likely milk or egg allergy, maternal ingestion of peanut during pregnancy was strongly associated with a high level of peanut sensitization. (J Allergy Clin Immunol 2010; 126:1191-7.)

• 出版日期2010-12