Automatic estimation of extent of resection and residual tumor volume of patients with glioblastoma

作者：Meier Raphael^*; Porz Nicole; Knecht Urspeter; Loosli Tina; Schucht Philippe; Beck Jurgen; Slotboom Johannes; Wiest Roland; Reyes Mauricio

来源：Journal of Neurosurgery, 2017, 127(4): 798-806.

DOI：10.3171/2016.9.JNS16146

• glioblastoma
• extent of resection
• residual tumor volume
• automatic tumor volumetry
• BraTumlA
• oncology

OBJECTIVE In the treatment of glioblastoma, residual tumor burden is the only prognostic factor that can be actively influenced by therapy. Therefore, an accurate, reproducible, and objective measurement of residual tumor burden is necessary. This study aimed to evaluate the use of a fully automatic segmentation method brain tumor image analysis (BraTumlA) for estimating the extent of resection (EOR) and residual tumor volume (RTV) of contrast-enhancing tumor after surgery.
METHODS The imaging data of 19 patients who underwent primary resection of histologically confirmed supratentorial glioblastoma were retrospectively reviewed. Contrast-enhancing tumors apparent on structural preoperative and immediate postoperative MR imaging in this patient cohort were segmented by 4 different raters and the automatic segmentation BraTumlA software. The manual and automatic results were quantitatively compared.
RESULTS First, the interrater variabilities in the estimates of EOR and RTV were assessed for all human raters. Interrater agreement in terms of the coefficient of concordance (W) was higher for RTV (W = 0.812; p < 0.001) than for EOR (W = 0.775; p < 0.001). Second, the volumetric estimates of BraTumlA for all 19 patients were compared with the estimates of the human raters, which showed that for both EOR (W = 0.713; p < 0.001) and RTV (W = 0.693; p < 0.001) the estimates of BraTumlA were generally located close to or between the estimates of the human raters. No statistically significant differences were detected between the manual and automatic estimates. BraTumlA showed a tendency to overestimate contrast-enhancing tumors, leading to moderate agreement with expert raters with respect to the literature based, survival-relevant threshold values for EOR.
CONCLUSIONS BraTumlA can generate volumetric estimates of EOR and RTV, in a fully automatic fashion, which are comparable to the estimates of human experts. However, automated analysis showed a tendency to overestimate the volume of a contrast-enhancing tumor, whereas manual analysis is prone to subjectivity, thereby causing considerable interrater variability.

• 出版日期2017-10