Asymmetric hydroamination/cyclization catalyzed by group 4 metal complexes with chiral biaryl-based ligands

作者：Zi, Guofu^*

来源：Journal of Organometallic Chemistry, 2011, 696(1): 68-75.

DOI：10.1016/j.jorganchem.2010.07.034

• Group 4 metals
• Chiral catalysts
• Asymmetric catalysis
• Hydroamination/cyclization

Group 4 metal complexes based on chiral biaryl ligands are readily prepared by a convenient amine elimination procedure, and they are efficient catalysts for the asymmetric hydroamination/cyclization of aminoalkenes. The biaryl-based ligands are highly modular enabling facile tuning of the catalyst reactivity and selectivity. The corresponding heterocyclic products have been obtained in excellent enantiomeric excesses (up to 93%) using sterically hindered C-2-symmetric titanium and zirconium mesitoylamidate complexes such as [1,1'-(C10H10)(2)-2,2'-{NCO(2,4,6-Me3C6H2)}(2)]M(NMe2)(2) (M = Ti, Zr). These results are presented in this short review.

• 出版日期2011-1-1
• 单位北京师范大学