A novel beta-lactam derivative, albactam from the flowers of Albizia lebbeck with platelets anti-aggregatory activity in vitro

作者:El Gamal Ali Ali*; Abd El Halim Mohamed Farag; Kalil Ashraf Taha; Basudan Omer Ahmed; Al Rehaily Adnan Jathlan; Ahmad Mohamed Shamim; El Tahir Kamal Hussin; Al Massarani Shaza Mohamed; Abdel Mageed Wael Moustafa
来源:Pakistan Journal of Pharmaceutical Sciences, 2015, 28(2): 745-753.

摘要

A novel beta-lactam derivative, albactam, was isolated from the alcoholic extract of the flowers of Albizia lebbeck. It showed a significant anti-aggregatory activity against adenosine diphosphate and arachidonic acid induced guinea-pigs' platelets aggregation in vitro. Six more known compounds were also isolated and fully characterized by measuring 1D and 2D NMR, two of them are the triterpenes beta- amyrin and 11 alpha, 12 alpha-oxidotaraxerol, two ceramide derivatives and two flavonoids, kampferol 3-O-rutinoside and rutin.

  • 出版日期2015-3